Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation

The dynamic nature of the nuclear envelope (NE) is often underestimated. NE protects, regulates, and organizes eukaryote genome adapts to epigenetic changes its environment. morphology characterized by a wide range diversity abnormality such as invagination blebbing, it diagnostic factor for pathologies cancer. Recently, micronuclei, small nucleus that contains full chromosome or fragment thereof, has gained much attention. micronuclei prone collapse, leading DNA release into cytoplasm with consequences ranging from activation cGAS/STING pathway, an innate immune response, creation chromosomal instability. discovery those mechanisms revolutionized understanding some inflammation-related diseases origin complex rearrangements, observed during initiation tumorigenesis. Herein, we will highlight complexity biology discuss clinical symptoms in NE-related diseases. interplay between immunity, genomic instability, leakage could be major focus future years explain lead new classes therapeutics.